Long-term diabetic complications as predictors of foot ulcers healing failure: A retrospective study in a tertiary-care center. (May 2020)

• Record Type: Journal Article
• Authors: Caruso, Paola; Longo, Miriam; Gicchino, Maurizio; Scappaticcio, Lorenzo; Caputo, Mariangela; Maiorino, Maria Ida; Bellastella, Giuseppe; Esposito, Katherine
• Is Part Of: Diabetes research and clinical practice. Volume 163(2020)
• Publication Date: 2020-05
• Subjects: Type 2 diabetes -- Diabetic complications -- Diabetic foot ulcer -- Diabetic kidney disease -- Charcot arthropathy -- Healing failure; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2020.108147
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aim: The aim of this study was to investigate the factors involved in healing failure in a population of patients with diabetic foot ulcers (DFU) after one year of follow-up. Methods: One hundred and forty-four patients were treated for DFU in a tertiary-care center and had a regular follow-up for one year. Laboratory measurements and clinical assessments, including long-term diabetes complications and risk factors for DFU, were collected at baseline and patients were divided in two groups according to the outcome [Healed group (H, n = 91), and Not Healed group (NH, n = 53)]. Results: Compared with H group, NH group had significant higher levels of urinary albumin excretion [H vs NH, median (IQR), 23.5 (10.1, 41.1) vs 26.4 (20.8, 141.1), P = 0.032] and significantly increased prevalence of diabetic kidney disease (DKD) (22% vs 40%, P = 0.038) and Charcot Arthropathy (3% vs 16%, P = 0.025). No differences among the other long-term complications of diabetes, risk factors for DFU or clinical features were found. The multiple logistic regression analysis identified DKD and Charcot Arthropathy as negative predictors of healing. Conclusions: In a population of people with type 2 diabetes with DFU treated in a tertiary-care center, DKD and Charcot Arthropathy were related to poor healing within one year-follow-up.