Mulberry supplementation reduces lipid deposition and protects hamster retina from oxLDL damage. (August 2020)

• Record Type: Journal Article
• Authors: Wu, Chiao-Sen; Chung, Tai-Jung; Lee, Yi-Ju; Hsu, Jeng-Dong; Lee, Huei-Jane
• Is Part Of: Journal of functional foods. Volume 71(2020)
• Publication Date: 2020-08
• Subjects: Mulberry -- Retina -- Adult retinal pigment epithelial cell -- Oxidized low-density lipoprotein -- High fat diet; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104007
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Mulberry reduce lipid deposition and oxLDL to ameliorate retinopathy in hamster fed with high fat diet. Mulberry protected RPE from oxLDL-caused cell death. Mulberry inhibited oxLDL to enter cell via regulating the oxLDL receptor. Abstract: Patients with age-related macular degeneration typically exhibit an accumulation of oxidized low-density lipoprotein (oxLDL) in the retinal Bruch's membrane. Retinal pigment epithelial (RPE) cells were found to engulf oxLDL, triggering apoptosis. Mulberry and its anthocyanin might reduce oxLDL and lipid deposition in individuals consuming high-cholesterol diet. To investigate the relationship between mulberry water extract (MWE) intake and oxLDL in eye protection, Syrian hamsters fed a high fat diet (HFD) were used herein. After 8 weeks of treatment, MWE was found to reduce lipid deposition in hamsters' retinas. MWE also reduced the level of oxLDL and lipid peroxidation in eye specimens. Mulberry protected RPE cells from oxLDL-induced cell death and could inhibit the entry of oxLDL into cells by reducing the oxLDL receptor. Taken together, our results indicate that both in HFD fed hamsters and in oxLDL-treated ARPE cells, mulberry can reduce oxLDL accumulation to protect the retina from oxLDL-induced damage.