Visible-light induced synthesis of biocompatible porous polymers from oligocarbonatedimethacrylate (OСM-2) in the presence of dialkyl phthalates. (27th March 2020)

• Record Type: Journal Article
• Authors: Yudin, V.V.; Kovylin, R.S.; Baten'kin, M.A.; Kulikova, T.I.; Aleynik, D. Ya.; Egorikhina, M.N.; Rubtsova, Yu. P.; Charykova, I.N.; Mlyavykh, S.G.; Chesnokov, S.A.; Fedushkin, I.L.
• Is Part Of: Polymer. Volume 192(2020)
• Publication Date: 2020-03-27
• Subjects: Photopolymerization -- Biocompability -- Porous polymers -- Mesenchymal stem cells -- Cytotoxicity; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2020.122302
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: Polymer monoliths containing open interconnected pores were synthesized by a visible-light induced polymerization of oligocarbonatedimethacrylate (OCM-2) in the presence of dialkylphthalates (C6 H4 [C(O)OR]2, R = C2 H5, n -C4 H9, n -C8 H17 and n -C9 H19 ) as porogenic agent. A closeness of the refractive indices of the forming polymer and dialkylphthalates provides for the formation of transparent porous monoliths, thus making manufacture of thick porous polymeric materials using visible light possible. The porous polymers derived from OCM-2 can sorb water and benzene. The filling of pores by water increases with an increase of a number of carbon atoms in the ester groups from 0.65 for diethyl phthalate to 1.0 for dinonyl phthalate. Experimentally defined value of Hildebrand solubility parameter δ for poly-OCM-2 is 24.9 MPa 1/2 . A closeness of the solubility parameters of the polymer ( δ p ) and porogenic agent ( δ s ) guarantees the porous architecture of the polymer formed. The porous polymeric materials have been studied in vitro using a culture of human dermal fibroblasts (HDF) of four passages. The MTT test (MTT is 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) has shown that the materials are not cytotoxic. During long-term cultivation of the cells on the material surface a pronounced cell adhesion as well as cell viability and proliferative activity have been detected. Graphical abstract: Image 10106 Highlights: Polymers containing open pores were synthesized by a visible light polymerization. These materials are not cytotoxic and were studied in vitro using dermal fibroblasts. The obtained cell scaffolds have a thickness of up to 4 mm.