Bacillus natto regulates gut microbiota and adipose tissue accumulation in a high-fat diet mouse model of obesity. (May 2020)

• Record Type: Journal Article
• Authors: Wang, Pinggui; Gao, Xiang; Li, Yan; Wang, Shanglong; Yu, Jia; Wei, Yuxi
• Is Part Of: Journal of functional foods. Volume 68(2020)
• Publication Date: 2020-05
• Subjects: Bacillus natto -- Lactobacillus plantarum -- Obesity -- Lipid metabolism -- Gut microbiota; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.103923
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: The direct anti-obesity of Bacillus natto is investigated for the first time. The mechanism of B. natto regulating metabolic disorders was explored in obese mice. B. natto could alter gut microbes to improve the High-fat diet (HFD) induced obesity. B. natto potentially serves as a probiotic to prevent obesity and metabolic disorders. Abstract: The direct treatment of obesity and its associated metabolic disorders using Bacillus natto was investigated in a high-fat diet (HFD) obesity mouse model. After 8 weeks of treatment, B. natto significantly reduces the body, epididymal fat, perirenal fat, liver, and spleen weight of obese mice, and reduces serum triglyceride and total cholesterol. B. natto also reduces alanine transferase, aspartate aminotransferase, total bilirubin, and total bile acid, and decreases fat cell area and fat droplets in the liver, compared with the untreated HFD group. B. natto can inhibit fatty acid synthesis and promote fatty acid catabolism in the liver through expression of Pparα and Srebp-1c. Metagenomic analysis of gut microbiota showed that B. natto increased the ratio of Bacteroidetes to Firmicutes and increased the abundance of Verrucomicrobia to improve obesity. These results provide a scientific basis for B. natto as a potential probiotic to prevent obesity and metabolic disorders.