Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization. (February 2020)

• Record Type: Journal Article
• Authors: De Greve, Henri; Virdi, Vikram; Bakshi, Shruti; Depicker, Ann
• Is Part Of: Current opinion in biotechnology. Volume 61(2020)
• Page Start: 96
• Page End: 101
• Publication Date: 2020-02
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2019.11.006
• Languages: English
• ISSNs: 0958-1669

Abstract

Abstract : Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.