Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han. (July 2020)

• Record Type: Journal Article
• Authors: Hu, Lili; Tan, Handan; Cao, Qingfeng; Yuan, Gangxiang; Huang, Changwei; Su, Guannan; Kijlstra, Aize; Yang, Peizeng
• Is Part Of: Experimental eye research. Volume 196(2020)
• Publication Date: 2020-07
• Subjects: Behcet's disease -- Single nucleotide polymorphism -- TNFSF -- TNFRSF -- Immune response -- Autoinflammatory disease -- Immunogenetics; Ophthalmology -- Periodicals; Eye -- Periodicals; Œil -- Périodiques; Ophthalmology; Periodicals; Electronic journals; 612.8405
• DOI: 10.1016/j.exer.2020.108045
• Languages: English
• ISSNs: 0014-4835

Abstract

Abstract: The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX® technology. Data were analyzed using a Chi-square (χ2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD ( P c = 0.013, OR = 1.233, 95% CI = 1.103–1.379: P c = 0.013, OR = 0.811, 95% CI = 0.725–0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population. Highlights: We designed the population-based two-phase case-control study. Identification of a novel SNP rs1800692 associated with BD in a Chinese Han population. The polymorphism of TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population. Our data provides a new insight into the role of TNF pathway in BD and may lead to novel treatments.