Acridine Variations for Coordination Chemistry. Issue 3 (12th March 2020) - Omolo, Kevin O.
Abstract: This study describes the synthesis of an acridone through the directed lithiation of a diarylamine, and elaboration via the 4, 5‐dibromoacridone. The bromo substituents are amenable to Suzuki‐Miyaura coupling. Conversion to a 9‐chloro‐4, 5‐dibromoacridine, followed by bromine‐lithium exchange, allows the preparation of a 4, 5‐bis (phosphino)‐9‐chloroacridine. The 9‐chloro moiety undergoes nucleophilic aromatic substitution by methoxide or an aryloxide. One‐electron reduction of a 9‐(aryloxy)‐4, 5‐bis(phosphino)acridine affords a stable radical anion. Abstract :