A Tetrakisquinoline Analog of Calcium Indicator Quin2 for Fluorescence Detection of Cd2+. Issue 9 (24th February 2020)

• Record Type: Journal Article
• Authors: Mikata, Yuji; Kaneda, Minori; Tanaka, Marin; Iwatsuki, Satoshi; Konno, Hideo; Matsumoto, Arimasa
• Is Part Of: European journal of inorganic chemistry. Issue 9(2020)
• Page Start: 757
• Page End: 763
• Publication Date: 2020-02-24
• Subjects: Cadmium -- N ligands -- Fluorescence -- Sensors -- Structure‐activity relationships; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201901323
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : Quin2 (2‐{2‐[bis(carboxymethyl)amino‐5‐methylphenoxy]methyl}‐6‐methoxy‐8‐[bis(carboxymethyl)amino]quinoline) is a well‐known fluorescent Ca 2+ indicator. In this study, we replaced its four carboxy groups with quinolines and deleted a methyl group on the benzene ring to afford TQquin2 [ N, N, N', N' ‐tetrakis(2‐quinolylmethyl)‐8‐amino‐2‐(2‐aminophenoxy)methyl‐6‐methoxyquinoline]. In methanol solution, TQquin2 exhibited fluorescence enhancement toward Cd 2+ with excellent selectivity. Abstract : Replacement of carboxylate to quinoline in quin2 (2‐{2‐[bis(carboxymethyl)amino‐5‐methylphenoxy]methyl}‐6‐methoxy‐8‐[bis(carboxymethyl)amino]quinoline) structure exhibits Cd 2+ ‐specific fluorescence enhancement in methanol.