Chronic toxicity study in Sprague-Dawley rats on transgenic rice T1c-19 with cry1C* gene. (June 2020)

• Record Type: Journal Article
• Authors: Tang, Xiaoqiao; Wang, Yangfeng; Pei, Lanjie; Yang, Wenxiang; Fan, Jun; Zhuo, Qin; Yang, Xiaoguang; Yu, Zhou; Jia, Xudong; Liu, Jiafa; Fan, Bolin
• Is Part Of: Food and chemical toxicology. Volume 140(2020)
• Publication Date: 2020-06
• Subjects: Genetically modified rice -- Toxicity -- cry1C* -- Safety evaluation -- Rats; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111324
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: In the present study, a novel transgenic rice line T1c-19 carrying cry1C* gene was evaluated in Sprague-Dawley (SD) rats by a 52-week feeding study, aiming at determining its unintended effects. The rice T1c-19 and its parental rice were prepared at a level of up to 60.75% in the growth diet and 66.75% in the maintenance diet, respectively. AIN-93 diet was used as a nutritional control. All the diets were nutritionally balanced. Each group, with 48 rats of both genders, was fed the corresponding diet for 52 weeks. The results of clinical signs, body weight and food consumption of the transgenic rice group were comparable to those of the parental rice group. Clinical measurements were made on weeks 13, 26 and 52, and statistical significances were observed in several hematological and serum biochemical indices between the two rice groups and were not considered as treatment-related. The terminal histopathological examination showed some spontaneous lesions in all groups with no significant difference among them. Taken together, the results of the present 52-week chronic toxicity study of transgenic rice T1c-19 exerted no unintended adverse effects on SD rats. Highlights: Chronic toxicity of transgenic rice T1c-19 in Sprague-Dawley rats was studied. GM rice was formulated at 60.75% in growth diets and 66.75% in maintenance diets. Sporadic statistical differences were observed in several indices. No toxic effects were detected in rats after 52-weeks' consumption of rice T1c-19.