Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome. (20th February 2020)

• Record Type: Journal Article
• Authors: Kourelis, Taxiarchis V.; Jevremovic, Dragan; Jessen, Erik; Dasari, Surendra; Villasboas, Jose C.; Dispenzieri, Angela; Kumar, Shaji
• Is Part Of: British journal of haematology. Volume 190:Number 1(2020)
• Page Start: 79
• Page End: 83
• Publication Date: 2020-02-20
• Subjects: myeloma -- immunophenotyping -- immunohaematology -- tumour immunology; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.16522
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: We sought to dissect the tumour microenvironment in a small cohort ( N = 10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45 + and CD3 + compartments. Double positive T cells and PD‐1 positive CD4 T cells were expanded and naïve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic‐driven selection as a driver of disease pathogenesis in POEMS.