Specialized RSC: Substrate Specificities for a Conserved Chromatin Remodeler. (3rd June 2020)

• Record Type: Journal Article
• Authors: Hainer, Sarah J.; Kaplan, Craig D.
• Is Part Of: BioEssays. Volume 42:Number 7(2020:Jul.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-03
• Subjects: chromatin remodeler -- H2AZ -- histone variant -- nucleosome -- RSC; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.202000002
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract: The remodel the structure of chromatin (RSC) nucleosome remodeling complex is a conserved chromatin regulator with roles in chromatin organization, especially over nucleosome depleted regions therefore functioning in gene expression. Recent reports in Saccharomyces cerevisiae have identified specificities in RSC activity toward certain types of nucleosomes. RSC has now been shown to preferentially evict nucleosomes containing the histone variant H2A.Z in vitro. Furthermore, biochemical activities of distinct RSC complexes has been found to differ when their nucleosome substrate is partially unraveled. Mammalian BAF complexes, the homologs of yeast RSC and SWI/SNF complexes, are also linked to nucleosomes with H2A.Z, but this relationship may be complex and extent of conservation remains to be determined. The interplay of remodelers with specific nucleosome substrates and regulation of remodeler outcomes by nucleosome composition are tantalizing questions given the wave of structural data emerging for RSC and other SWI/SNF family remodelers. Abstract : Remodel the structure of chromatin (RSC) represents a highly conserved class of chromatin remodeling factors, able to alter chromatin structure in eukaryotes by altering nucleosome position or occupancy. Recent work suggests that RSC can have altered activity on nucleosomes of distinct protein composition or structure. Such distinct activities may represent a paradigm for remodeler specificity or activity on different nucleosomes.