Intravenous vitamin K1 normalises prothrombin time in 1 hour in dogs with anticoagulant rodenticide toxicosis. Issue 6 (18th March 2020)

• Record Type: Journal Article
• Authors: Mooney, ET; Agostini, G; Griebsch, C; Hickey, M
• Is Part Of: Australian veterinary journal. Volume 98:Issue 6(2020)
• Page Start: 225
• Page End: 231
• Publication Date: 2020-03-18
• Subjects: anaphylactoid -- dogs -- phytomenadione -- rodenticide -- vitamin K1; Veterinary medicine -- Australia -- Periodicals; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/avj.12931
• Languages: English
• ISSNs: 0005-0423

Abstract

Abstract : Four dogs with anticoagulant rodenticide toxicosis were treated with intravenous vitamin K1 in lieu of plasma transfusion due to client cost constraints. Two dogs experienced a suspected anaphylactoid reaction, necessitating cessation of the treatment in one dog. Prothrombin time was rechecked 1 h after treatment in the remaining three dogs and all results were within the normal reference range. All four dogs were discharged from hospital within 48 h of presentation. Intravenous vitamin K1 rapidly reverses the coagulopathic state in dogs with anticoagulant rodenticide toxicosis. It is a viable alternative therapy to plasma transfusion if circumstances preclude its use; however, patients must be monitored for anaphylactoid reactions.