The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019. Issue 7 (5th June 2020)

• Record Type: Journal Article
• Authors: Liu, Tao; Zhang, Jieying; Yang, Yuhui; Ma, Hong; Li, Zhenyu; Zhang, Jiaoyue; Cheng, Ji; Zhang, Xiaoyun; Zhao, Yanxia; Xia, Zihan; Zhang, Liling; Wu, Gang; Yi, Jianhua
• Is Part Of: EMBO molecular medicine. Volume 12:Issue 7(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-05
• Subjects: biomarker -- coronavirus disease 2019 -- cytokine storm -- disease monitoring -- interleukin‐6; Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.202012421
• Languages: English
• ISSNs: 1757-4676

Abstract

Abstract: Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID‐19). The purpose of this study is to explore changes in markers of severe disease in COVID‐19 patients. Sixty‐nine severe COVID‐19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C‐reactive protein (CRP), ferritin, and D‐dimer was found in most severe cases. Baseline interleukin‐6 (IL‐6) was found to be associated with COVID‐19 severity. Indeed, the significant increase of baseline IL‐6 was positively correlated with the maximal body temperature during hospitalization and with the increased baseline of CRP, LDH, ferritin, and D‐dimer. High baseline IL‐6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL‐6 and improved CT assessment was found in patients during recovery, while IL‐6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL‐6 can be used as a marker for disease monitoring in patients with severe COVID‐19. Synopsis: Sixty‐nine severe COVID‐19 patients were analyzed for disease monitoring. Elevated baseline interleukin (IL)‐6 was found positively correlated to maximal body temperature, CRP, LDH, ferritin and D‐dimer during disease progression. IL‐6 increased during disease exacerbation and decreased during recovery. The IL‐6 level is associated with disease severity in severe cases of COVID‐19. The dynamic change in IL‐6 reflects the disease course of severe COVID‐19 cases. Abstract : Sixty‐nine severe COVID‐19 patients were analyzed for disease monitoring. Elevated baseline interleukin (IL)‐6 was found positively correlated to maximal body temperature, CRP, LDH, ferritin and D‐dimer during disease progression. IL‐6 increased during disease exacerbation and decreased during recovery.