Palladium‐Catalyzed peri‐Selective C−H Fluoroalkoxylation of Aryl Sulfoxides. Issue 13 (18th May 2020)

• Record Type: Journal Article
• Authors: Sato, Tomohiko; Nogi, Keisuke; Yorimitsu, Hideki
• Is Part Of: ChemCatChem. Volume 12:Issue 13(2020)
• Page Start: 3467
• Page End: 3471
• Publication Date: 2020-05-18
• Subjects: C−H functionalization -- fluoroalkoxylation -- palladium -- aryl sulfoxide -- peri-selective functionalization; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.202000485
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: Sulfinyl‐directed peri ‐selective C−H fluoroalkoxylation of aryl sulfoxides with fluorinated alcohols has been developed. By means of a palladium catalyst and PhI(OAc)2 as an oxidant, a range of fluoroalkoxy groups can be installed onto the peri position of aryl sulfoxides. The remaining sulfinyl groups on the fluoroalkoxylation products further promote Pummerer‐based C−H functionalizations. Abstract : C−H functionalizations : Sulfinyl‐directed peri ‐selective C−H fluoroalkoxylation of aryl sulfoxides with fluorinated alcohols has been developed. By means of a palladium catalyst and PhI(OAc)2 as an oxidant, a range of fluoroalkoxy groups can be installed onto the peri position of aryl sulfoxides. The remaining sulfinyl groups on the fluoroalkoxylation products further promote Pummerer‐based C−H functionalizations.