Global trends in oral and pharyngeal cancer incidence and mortality. Issue 4 (30th January 2020)

• Record Type: Journal Article
• Authors: Bosetti, Cristina; Carioli, Greta; Santucci, Claudia; Bertuccio, Paola; Gallus, Silvano; Garavello, Werner; Negri, Eva; La Vecchia, Carlo
• Is Part Of: International journal of cancer. Volume 147:Issue 4(2020)
• Page Start: 1040
• Page End: 1049
• Publication Date: 2020-01-30
• Subjects: age‐standardized rates -- incidence -- mortality -- oral and pharyngeal cancer -- trends; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.32871
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : To provide an up‐to‐date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010–2015, and, for selected most populous countries, over the period 1970–2016. For 12 largest countries, we analyzed incidence derived from Cancer Incidence in Five Continents in 1960–2012 for all oral and pharyngeal cancers and by subsites. In 2015, male age‐standardized (world population) death rates per 100, 000 were 5.03 in the European Union (EU), 8.33 in the Russian Federation, 2.53 in the United States (USA), and 3.04 in Japan; corresponding rates in women were 1.23, 1.23, 0.82, and 0.76. Male mortality decreased over the last decades in several European countries, with earlier and sharper declines in southern Europe; conversely, mortality was still increasing in a few eastern European countries and the United Kingdom. Mortality in men also decreased in Argentina, Australia, and Hong Kong, while it leveled off over more recent calendar years in Brazil, Japan, Mexico, the Republic of Korea, as well as in Australia and the USA. Female mortality slightly rose in various European countries. Overall incidence trends in the largest countries were broadly consistent with mortality ones, but oropharyngeal cancer incidence rose in many countries. Changes in tobacco and alcohol exposure in men over the last decades likely explain the favorable trends in oral and pharyngeal cancer mortality and incidence observed in selected countries worldwide, while increased human papillomavirus infection is likely responsible for the rise in oropharyngeal cancer incidence. Abstract : What's new? Trends in oral and pharyngeal cancer incidence and mortality historically have been associated with patterns in alcohol and tobacco use. This study, based on global incidence and death data, shows that specifically in men, over the last few decades, death rates for oral and pharyngeal cancer have continued to decline, mirroring favourable patterns in tobacco and alcohol consumption in various populations. Recent increases in oropharyngeal cancer incidence, however, particularly in Australia and the United States, parallel the rise of human papillomavirus infection in those regions.