Efficient Cu‐catalyzed Synthesis of Benzimidazoles Using Ammonia as Nitrogen Source in Water. Issue 7 (8th June 2020)

• Record Type: Journal Article
• Authors: Li, Minxin; Tang, Yanling; Gao, Hui; Rao, Gaoxiong; Mao, Zewei
• Is Part Of: Asian journal of organic chemistry. Volume 9:Issue 7(2020)
• Page Start: 1027
• Page End: 1031
• Publication Date: 2020-06-08
• Subjects: Cu-catalyzed -- Ullmann condensation -- o-halobenzanilides -- benzimidazoles -- ammonia aqueous; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202000236
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: In present work, we have developed an efficient strategy for the synthesis of 2‐substituted benzimidazoles via Cu‐catalyzed Ullmann condensation reaction of o ‐halobenzanilides with ammonia in water. This protocol is applicable to a wide variety of 2‐substituted benzimidazoles bearing functional groups tolerance, which features one‐pot, high yields, functional groups tolerable and green solvent. Abstract : Heterocycles : A newly developed Cu‐catalyzed Ullmann condensation reaction of o ‐halobenzanilides with ammonia has been presented, giving 2‐substituted benzimidazoles in high yields.