Population pharmacokinetics of ethanamizuril in normal and coccidiosis‐infected chickens through ultra‐performance liquid chromatography–Tandem Mass Spectrometry. Issue 4 (6th May 2020)

• Record Type: Journal Article
• Authors: Wang, Xiaoyang; Zhang, Keyu; Wang, Mi; Zhang, Lifang; Fei, Chenzhong; Wang, Chunmei; Liu, Yingchun; Xue, Feiqun; Hang, Taijun
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 43:Issue 4(2020)
• Page Start: 331
• Page End: 338
• Publication Date: 2020-05-06
• Subjects: chicken -- ethanamizuril -- population pharmacokinetics -- UPLC‐MSMS; Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12868
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract: Ethanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two‐compartment model with first‐order absorption after oral administration in chickens. Its clearance rate and volumn of central compartment distribution ( V c ) were affected by age and body weight, and volumn of central compartment distribution ( V c ) and volume of peripheral compartment distribution( V p ) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.