In vivo evolution of biopsy‐proven inflammatory demyelination quantified by R2t* mapping. Issue 6 (4th May 2020)

• Record Type: Journal Article
• Authors: Xiang, Biao; Wen, Jie; Lu, Hsiang‐Chih; Schmidt, Robert E.; Yablonskiy, Dmitriy A.; Cross, Anne H.
• Is Part Of: Annals of clinical and translational neurology. Volume 7:Issue 6(2020)
• Page Start: 1055
• Page End: 1060
• Publication Date: 2020-05-04
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.51052
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: A 35‐year‐old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient‐Recalled‐Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.