Electrosynthesis of C3 Alkoxylated Quinoxalin‐2(1H)‐ones through Dehydrogenative C–H/O–H Cross‐Coupling. Issue 11 (26th February 2020)

• Record Type: Journal Article
• Authors: Jiang, Xinpeng; Yang, Liechao; Ye, Zenghui; Du, Xiaofan; Fang, Liyun; Zhu, Yu; Chen, Keda; Li, Jianjun; Yu, Chuanming
• Is Part Of: European journal of organic chemistry. Issue 11(2020)
• Page Start: 1687
• Page End: 1694
• Publication Date: 2020-02-26
• Subjects: Quinoxalinone -- Electrosynthesis -- Cross Coupling -- Oxidation -- Alkoxylation; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901928
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A highly efficient electrochemically dehydrogenative C–H/O–H cross‐coupling between quinoxalin‐2(1 H )‐ones and alcohols was developed under mild conditions. Using different types of alcohols as solvent, various 3‐alkoxylated quinoxalin‐2(1 H )‐ones were synthesized in a simple undivided cell at room temperature. This novel electrochemical cross‐dehydrogenative coupling approach features broad functional group tolerance, metal‐ and oxidant‐free conditions, and moderate to good yields. Abstract : Various 3‐alkoxylated quinoxalin‐2(1 H )‐ones were synthesized in a simple undivided cell via electrochemically dehydrogenative C–H/O–H cross‐coupling between quinoxalin‐2(1 H )‐ones and alcohols under mild conditions.