Long‐Term Oxygen Storage Nanosystem for Near‐Infrared Light‐Triggered Oxygen Supplies to Antagonize Hypoxia‐Induced Therapeutic Resistance in Nasopharyngeal Carcinoma. (15th May 2020)

• Record Type: Journal Article
• Authors: You, Yuanyuan; Zhao, Zhennan; He, Lizhen; Sun, Zhibo; Zhang, Dong; Shi, Changzheng; Cheng, Qingqing; Liu, Yiyong; Luo, Liangping; Chen, Tianfeng
• Is Part Of: Advanced functional materials. Volume 30:Number 27(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-15
• Subjects: long‐term oxygen storage -- radiosensitization -- tumor hypoxia; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202002369
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: O2 ‐delivering nanosystems have been used to antagonize hypoxia‐induced tumor therapeutic resistance. However, short‐time oxygen storage is still a bottleneck for these O2 ‐delivering nanosystems, which results in a decrease in blood circulation time and accumulation of oxygen in tumors, thus reducing the tumor therapeutic efficacy. Herein, a long‐term oxygen storage nanosystem (O2 ‐PIr@Si@PDA) is designed to overcome hypoxia for the treatment of nasopharyngeal carcinoma. This nanosystem is constructed by using perfluorooctyl bromide (PFOB) core as the oxygen carrier, functionalized with an oxygen sensitive probe (Ir(III) complex) and subsequently enclosed with an ultrathin‐walled silica shell. Due to the silica shell, this nanosystem can store oxygen for longer than 7 days. The oxygen in the O2 ‐PIr@Si@PDA nanosystem can be released quickly with the temperature‐responsive rupture of the silicon shell under near‐infrared (NIR) irradiation. The oxygen storage and release can be self‐monitored using the Ir(III) complex with its luminescence effect. As expected, this multifunctional nanosystem in combination with NIR irradiation not only inhibits tumor growth by alleviating hypoxia, but also enhances the effect of oxygen‐sensitized radiotherapy against nasopharyngeal carcinoma. Taken together, this study offers a novel strategy for designing long‐term oxygen storing nanosystem to relieve tumor hypoxia, thus improving the precise cancer therapeutic efficacy. Abstract : A long‐term oxygen storage nanosystem has been designed to relieve tumor hypoxia and enhance chemoradiotherapy. This nanosystem can store oxygen for more than 7 days, release it quickly by temperature‐responsive silicon shell rupture under NIR laser irradiation, and self‐monitor the oxygen release from the nanosystem by using luminescent Ir(III) complex as a probe.