[3+2] Cycloaddition of Trifluoromethylated N‐Acylhydrazones with Azomethine Ylides: Synthesis of Trifluoromethylated Imidazolidines. Issue 7 (20th April 2020)

• Record Type: Journal Article
• Authors: Zhao, Fangxia; Wang, Ke‐Hu; Wen, Lan; Zhao, Zhuanxia; Hu, Yongqin; Xu, Weigang; Huang, Danfeng; Su, Yingpeng; Wang, Junjiao; Hu, Yulai
• Is Part Of: Asian journal of organic chemistry. Volume 9:Issue 7(2020)
• Page Start: 1036
• Page End: 1039
• Publication Date: 2020-04-20
• Subjects: azomethine ylides -- N-acylhydrazones -- imidazolidines -- cycloaddition -- trifuloromethylated compounds; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202000057
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: Trifluoromethylated N‐ acylhydrazones are used as dipolarophiles to perform 1, 3‐dipolar cycloadditions with azomethine ylides to afford trifluoromethylated 1, 2, 4, 5‐tetrasubstituted imidazolidines in good yields under mild conditions. The role switch of the trifluoromethylated N ‐acylhydrazones demonstrates that they are versatile trifluoromethyl building blocks for CF3 ‐containing heterocycles. Abstract : Trifluoromethylated N ‐acylhydrazones are used as dipolarophiles to perform 1, 3‐dipolar cycloaddition with azomethine ylides to afford trifluoromethylated 1, 2, 4, 5‐tetrasubstituted imidazolidines in good yields under mild conditions.