Cover Picture: Powering Artificial Enzymatic Cascades with Electrical Energy (Angew. Chem. Int. Ed. 27/2020). Issue 27 (28th April 2020)

• Record Type: Journal Article
• Authors: Al‐Shameri, Ammar; Petrich, Marie‐Christine; junge Puring, Kai; Apfel, Ulf‐Peter; Nestl, Bettina M.; Lauterbach, Lars
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 27(2020)
• Page Start: 10669
• Page End: 10669
• Publication Date: 2020-04-28
• Subjects: electrochemical biocatalysis -- hydrogenases -- imine reductases -- isotopic labeling -- N-heterocycles; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202005732
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Electrical energy powers an artificial enzymatic cascade in a continuous flow reactor. As reported in their Communication on page 10929, L. Lauterbach et al. combined electrolysis in a scalable platform with a H2 ‐ and O2 ‐dependent enzymatic cascade and separated both systems with a gas‐permeable membrane. The synthesis of N‐heterocycles from diamines is demonstrated with up to 99 % product formation along with excellent regioselective labeling with stable isotopes. Cover illustration: Jo Richers.