Pomalidomide‐bortezomib‐dexamethasone in relapsed or refractory multiple myeloma: Japanese subset analysis of OPTIMISMM. Issue 6 (13th May 2020)

• Record Type: Journal Article
• Authors: Sunami, Kazutaka; Matsue, Kosei; Suzuki, Kenshi; Takezako, Naoki; Shinagawa, Atsushi; Sakurai, Sanae; Tamakoshi, Hiromi; Biyukov, Tsvetan; Peluso, Teresa; Richardson, Paul
• Is Part Of: Cancer science. Volume 111:Issue 6(2020)
• Page Start: 2116
• Page End: 2122
• Publication Date: 2020-05-13
• Subjects: Japan -- lenalidomide refractory -- OPTIMISMM -- pomalidomide -- relapsed or refractory multiple myeloma; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.14415
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract: In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib and dexamethasone (PVd) significantly improved the progression‐free survival (PFS) and the overall response rate (ORR) vs bortezomib and dexamethasone (Vd) in patients with relapsed or refractory multiple myeloma. All patients were previously treated with lenalidomide (70% refractory to lenalidomide) and had received one to three prior regimens. Here we report the first efficacy and safety analysis of PVd vs Vd in Japanese patients with relapsed or refractory multiple myeloma. Seventeen patients enrolled in the OPTIMISMM trial in Japan. With a median follow‐up of 14.8 months, the median PFS was 17.6 months with PVd (n = 12) vs 4.4 months with Vd (n = 5), and the ORR was 100% vs 60.0%, respectively. The safety profile was as expected for PVd. Toxicities were managed with dose reductions and interruptions, and no patients discontinued PVd due to treatment‐emergent adverse events. These results are consistent with those in the overall OPTIMISMM patient population and confirm the clinical benefit of PVd in Japanese patients. Abstract : Here we report the efficacy and safety of PVd vs Vd in 17 patients with relapsed refractory multiple myeloma enrolled in the OPTIMISMM trial in Japan. With a median follow‐up of 14.8 months, median PFS was 17.6 months with PVd (n = 12) vs 4.4 months with Vd (n = 5), and ORR was 100% vs 60.0%, respectively; the safety profile with PVd was as expected. These results are consistent with those in the overall OPTIMISMM patient population and confirm the clinical benefit of PVd in Japanese patients.