Two New Abietane Diterpenoids from Selaginella moellendorffii Hieron. Issue 6 (7th May 2020)

• Record Type: Journal Article
• Authors: Wu, Wei; Jia, Xiao‐Hui; Zhang, Sha; Dong, Chun‐Mao; Kang, Feng‐Hua; Zou, Zhen‐Xing; Xu, Kang‐Ping
• Is Part Of: Chemistry & biodiversity. Volume 17:Issue 6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-07
• Subjects: Selaginella -- Selaginella moellendorffii -- abietane diterpenoid -- tetracyclic triterpenoid -- antiproliferative activity -- cytotoxic activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202000111
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Two new abietane diterpenoids, (3 S, 5 R, 10 S )‐3‐hydroxy‐12‐ O ‐demethyl‐11‐deoxy‐19(4→3)‐ abeo ‐cryptojaponol, 12, 19‐dihydroxyabieta‐8, 11, 13‐trien‐7‐one, were isolated from Selaginella moellendorffii Hieron., together with one known abietane diterpenoid and four known tetracyclic triterpenoids. Their structures were characterized by their 1D‐ and 2D‐NMR, ECD and mass spectral studies. All compounds were tested for their inhibitory effects on proliferation of three human cancer cells (human non‐small‐cell lung carcinoma cell lines A549 and human breast adenocarcinoma cell lines MDA‐MB‐231 and MCF‐7) in vitro . Among them, three compounds displayed modest cytotoxic activities against the above three human cancer cell lines with IC50 values ranging from 16.28 to 40.67 μM. Abstract :