Thermogenesis: Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes (Adv. Sci. 12/2020). Issue 12 (24th June 2020)

• Record Type: Journal Article
• Authors: Li, Jin; Pan, Xiaohan; Pan, Guihua; Song, Zijun; He, Yao; Zhang, Susu; Ye, Xueru; Yang, Xiang; Xie, Enjun; Wang, Xinhui; Mai, Xudong; Yin, Xiangju; Tang, Biyao; Shu, Xuan; Chen, Pengyu; Dai, Xiaoshuang; Tian, Ye; Yao, Liheng; Han, Mulan; Xu, Guohuan; Zhang, Huijie; Sun, Jia; Chen, Hong; Wang, Fudi; Min, Junxia; Xie, Liwei
• Is Part Of: Advanced science. Volume 7:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-24
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202070066
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number 1903366, Fudi Wang, Junxia Min, Liwei Xie, and co‐workers demonstrate the essential role of transferrin receptor 1 (Tfr1) in the thermogenic capacity and cell fate of brown/beige adipocytes. Under cold exposure, Tfr1 expression is transcriptionally regulated by hypoxia‐inducible factor 1α (HIF1α) in beige adipocytes. Targeting Tfr1 serves as a potential strategy for preventing and treating metabolic diseases.