Neuroimaging and neuropsychological assessment of freezing of gait in Parkinson's disease. Issue 1 (12th June 2018)

• Record Type: Journal Article
• Authors: Bluett, Brent; Banks, Sarah; Cordes, Dietmar; Bayram, Ece; Mishra, Virendra; Cummings, Jeffrey; Litvan, Irene
• Is Part Of: Alzheimer's & dementia. Volume 4:Issue 1(2018)
• Page Start: 387
• Page End: 394
• Publication Date: 2018-06-12
• Subjects: Neuroimaging -- Neuropsychology -- Gait -- Parkinson's disease; Dementia -- Periodicals; Dementia -- Treatment -- Periodicals; Alzheimer's disease -- Treatment -- Periodicals; Alzheimer's disease -- Periodicals; 616.831
• DOI: 10.1016/j.trci.2018.04.010
• Languages: English
• ISSNs: 2352-8737

Abstract

Abstract: Introduction: Freezing of gait (FOG) is a disabling phenomenon characterized by a brief, episodic absence or reduction of forward progression of the feet despite the intention to walk. It is a common cause of falls and mortality in cases with Parkinson's disease (PD). This article reviews neuropsychological and neuroimaging studies to date and introduces a new study of multimodal imaging and cognition in PD‐FOG. Methods: A comprehensive literature search identified studies using neuropsychological evaluation and/or neuroimaging to evaluate PD‐FOG. Results: Several studies have evaluated PD‐FOG, but few have combined neuropsychological and comprehensive neuroimaging and none longitudinally. Discussion: A study using a combined approach longitudinally evaluating cognitive dysfunction and underlying neural networks in FOG is needed. We introduce the framework of a study which demonstrates the use of establishing an infrastructure for studying neurodegenerative disorders using the National Institutes of Health/National Institute of General Medical Science Center of Biomedical Research Excellence grant mechanism.