Dietary patterns and β‐amyloid deposition in aging Australian women. Issue 1 (13th October 2018)

• Record Type: Journal Article
• Authors: Hill, Edward; Clifton, Peter; Goodwill, Alicia M.; Dennerstein, Lorraine; Campbell, Stephen; Szoeke, Cassandra
• Is Part Of: Alzheimer's & dementia. Volume 4:Issue 1(2018)
• Page Start: 535
• Page End: 541
• Publication Date: 2018-10-13
• Subjects: Biomarkers -- Alzheimer's disease -- Neuropathology -- β‐amyloid protein -- Diet -- Nutrition -- Dietary pattern -- Factor analysis -- Women; Dementia -- Periodicals; Dementia -- Treatment -- Periodicals; Alzheimer's disease -- Treatment -- Periodicals; Alzheimer's disease -- Periodicals; 616.831
• DOI: 10.1016/j.trci.2018.09.007
• Languages: English
• ISSNs: 2352-8737

Abstract

Abstract: Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid‐β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women. Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F‐18 florbetaben positron emission tomography scanning. Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m 2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03). Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease. Highlights: This is the first study to investigate dietary/cerebral Aβ relationships in women only. Four dietary patterns extrapolated by principal component analysis. Adherence to the junk food pattern is a significant predictor of Aβ deposition. These findings support the notion of diet as a modifiable risk factor for AD.