Investigation of α/γ hybrid peptide self‐assembled structures with antimicrobial and antibiofilm properties. (9th March 2020)

• Record Type: Journal Article
• Authors: Shankar, Sudha; Singh, Gurpreet; Rahim, Junaid Ur; Qayum, Arem; Sharma, Parduman R.; Katoch, Meenu; Rai, Rajkishor
• Is Part Of: Journal of peptide science. Volume 26:Number 4/5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-09
• Subjects: antibacterial -- biofilm inhibition -- drug delivery -- hybrid peptide -- self‐assembly -- supramolecular; Peptides -- Periodicals; Peptides -- Periodicals; 572.65
• DOI: 10.1002/psc.3243
• Languages: English
• ISSNs: 1075-2617

Abstract

Abstract : The present work describes the synthesis and characterization of α/γ hybrid peptides, Boc‐Phe‐γ 4 ‐Phe‐Val‐OMe, P1 ; Boc‐Ala‐γ 4 ‐Phe‐Val‐OMe, P2 ; and Boc‐Leu‐γ 4 ‐Phe‐Val‐OMe, P3 together with the formation of self‐assembled structures formed by these hybrid peptides in dimethyl sulfoxide (DMSO)/water (1:1). The self‐assembled structures were characterized by infrared (IR) spectroscopy, circular dichroism (CD), and scanning electron microscopy (SEM). Further, α/γ hybrid peptide self‐assembled structures were evaluated for antibacterial properties. Among all, the self‐assembled peptide P1 exhibited the antimicrobial activity against Escherichia coli and Klebsiella pneumoniae, while self‐assembled peptide P3 inhibited the biofilms of Salmonella typhimurium and Pseudomonas aeruginosa . In this study, we have shown the significance of self‐assembled structures formed from completely hydrophobic α/γ hybrid peptides in exploring the antibacterial properties together with biofilm inhibition. Abstract : Investigation of α/γ hybrid peptide self‐assembled structures with antimicrobial properties