A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study. Issue 12 (19th July 2018) - Bseikri, Mustafa
ABSTRACT: Asthma in the obese is often severe, difficult to treat, and characterized by less eosinophilic inflammation than asthma in the nonobese. Obesity‐associated metabolic dysregulation may be a causal factor. We previously reported that a nutrient‐ and fiber‐dense bar [Children's Hospital Oakland Research Institute (CHORI)‐bar], which was designed to fill gaps in poor diets, improved metabolism in healthy overweight/obese (OW/OB) adults. In this pilot trial, OW/OB adolescents with poorly controlled asthma were randomized to weekly nutrition/exercise classes with or without twice‐daily CHORI‐bar consumption. Intent‐to‐treat analysis did not indicate CHORI‐bar‐specific effects. However, restricting the analysis to participants with acceptable compliance and a relatively low fraction of exhaled nitric oxide (FENO; <50/ppb, a surrogate for noneosinophilic asthma; study participants: CHORI‐bar, n = 16; controls, n = 15) indicated that CHORI‐bar‐specific, significant improvements in lung function (forced vital capacity, percent‐predicted forced expiratory volume in 1 s, and percent‐predicted forced expiratory flow between 25 and 75% of forced vital capacity), primarily in participants with low chronic inflammation (high‐sensitivity C‐reactive protein <1.5 mg/L). (We previously observed that chronic inflammation blunted CHORI‐bar‐induced metabolic improvements in healthy OW/OB adults.) Lung function improvement occurred without weight loss and was independent of improvements in metabolic and anthropometric end points and questionnaire‐based measures of asthma control and quality of life. This study suggests that a nutritional intervention can improve lung function in OW/OB adolescents with asthma and relatively low FENO without requiring major changes in dietary habits, lifestyle, or weight loss and that this effect is blunted by chronic inflammation.—Bseikri, M., McCann, J. C., Lal, A., Fong, E., Graves, K., Goldrich, A., Block, D., Gildengoren, G. L., Mietus‐Snyder, M., Shigenaga, M., Suh, J., Hardy, K., Ames, B. N. A novel nutritional intervention improves lung function in overweight/obese adolescentswith poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study. FASEB J . 32, 6643–6654 (2018). www.fasebj.org