Bifunctional RNA‐Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent. Issue 16 (27th February 2020)

• Record Type: Journal Article
• Authors: Spelkov, Aleksandr A.; Goncharova, Ekaterina A.; Savin, Artemii M.; Kolpashchikov, Dmitry M.
• Is Part Of: Chemistry. Volume 26:Issue 16(2020)
• Page Start: 3489
• Page End: 3493
• Publication Date: 2020-02-27
• Subjects: binary probes -- deoxyribozymes -- DNA -- fluorescence -- RNA recognition -- theranostics; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201905528
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders. Abstract : Two birds with one stone : A DNA association can complete both RNA‐cleaving (therapeutic) and RNA‐detecting (diagnostic) functions.