Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis. Issue 5 (24th February 2020)

• Record Type: Journal Article
• Authors: Xing, Peter Yuli; Pettersson, Sven; Kundu, Parag
• Editors: Chung, Maxey C. M.; Kennedy, Brian K.
• Is Part Of: Proteomics. Volume 20:Issue 5/6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-24
• Subjects: gut microbiota -- intestinal epithelial renewal -- intestinal stem cells -- metabolites; Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201800419
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract: Microorganisms that colonize the gastrointestinal tract, collectively known as the gut microbiota, are known to produce small molecules and metabolites that significantly contribute to host intestinal development, functions, and homeostasis. Emerging insights from microbiome research reveal that gut microbiota‐derived signals and molecules influence another key player maintaining intestinal homeostasis—the intestinal stem cell niche, which regulates epithelial self‐renewal. In this review, the literature on gut microbiota‐host crosstalk is surveyed, highlighting the effects of gut microbial metabolites on intestinal stem cells. The production of various classes of metabolites, their actions on intestinal stem cells are discussed and, finally, how the production and function of metabolites are modulated by aging and dietary intake is commented upon.