Fluorescent pH‐Responsive Mesoporous Silica Nanoparticles with Core‐Shell Feature as a Traceable Delivery Carrier for Ibuprofen. Issue 20 (27th May 2020)

• Record Type: Journal Article
• Authors: Wei, Tingting; Sheng, Mengdi; Liu, Chang; Sun, Jihong; Wu, Xia; Bai, Shiyang
• Is Part Of: ChemistrySelect. Volume 5:Issue 20(2020)
• Page Start: 6123
• Page End: 6130
• Publication Date: 2020-05-27
• Subjects: Drug delivery -- Fluorescence -- Ibuporfen -- Mesoporous materials -- Silica; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202000934
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The fluorescent pH‐responsive mesoporous silica nanoparticles (P@BMMs) were prepared, in which, the (2‐[3‐(triethoxysilyl) propyl]‐1H‐Benz [de]isoquinoline‐1, 3(2H)‐dione) ‐ poly(acrylic acid) (PID‐PAA) shell was covalently anchored onto the vinyl‐modified surface of the bimodal mesoporous materials (BMMs) core via one‐step or two‐step process. Their structural features were analyzed by XRD, SEM, TEM, TG, and SAXS, and the results showed that P@BMMs possessed typical fractal features from structural irregularity to surface roughness. Ibuprofen as a model drug was loaded into the mesopore channels of BMMs cores, particularly, the drug‐releasing performances from P@BMMs carriers were pH‐dependent. Meanwhile, the photoluminescent emission spectra and the fluorescent decay profiles presented that the hybrid P@BMMs with strong fluorescent intensity at 395 nm and 450 nm and longer decay lifetimes (such as 3.53 and 18.86 ns for P@BMMs‐I‐10) is a promising drug carrier, which can be used in potential applications for controlled drug delivery. Abstract : The PID‐PAA ((2‐[3‐(triethoxysilyl) propyl]‐1H‐Benz [de]isoquinoline‐1, 3(2H)‐dione) ‐ poly(acrylic acid)) copolymer was successfully encapsulated on the vinyl‐modified surface of mesoporous BMMs, and thereafter the fluorescent pH‐responsive hybrid P@BMMs with core‐shell structure were prepared, which showed the strong fluorescent property and long decay lifetimes. Meanwhile, the IBU‐releasing performance from hybrid P@BMMs carrier was pH‐dependent. Their fractal features from structure irregularity to surface roughness were analyzed.