Detection of Dexamethasone Sodium Phosphate in Blood Plasma: Application of Hematite in Electrochemical Sensors. Issue 6 (3rd February 2020)

• Record Type: Journal Article
• Authors: Mazloum‐Ardakani, Mohammad; Sadri, Najva; Eslami, Vahid
• Is Part Of: Electroanalysis. Volume 32:Issue 6(2020)
• Page Start: 1148
• Page End: 1154
• Publication Date: 2020-02-03
• Subjects: Hematite nanoparticles -- Graphene oxide nanosheets -- Dexamethasone sodium phosphate -- Differential pulse voltammetry.; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201900498
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: We studied sensor application of a graphene oxide and hematite (α‐Fe2 O3 /GO) composite electrode well‐characterized by the SEM and XRD. Through differential pulse voltammetry (DPV), oxidation of dexamethasone sodium phosphate (DSP) was studied at the surface of a glassy carbon electrode (GCE) modified with graphene oxide nanosheets (GO) and the α‐Fe2 O3 /GO composite. The values of the transfer coefficient (α) and the diffusion coefficient (D) of DSP were 0.5961 and 4.71×10 −5 cm 2 s −1 respectively. In the linear range of 0.1–50 μM, the detection limit (DL) was 0.076 μM. In the second step, a GCE was modified with α‐Fe2 O3 /GO composite and the DSP measurement step was repeated to analyzed and compare the effects of hematite nanoparticles present on graphene oxide surfaces. According to the results, α and D were 0.52 and 2.406×10 −4 cm 2 s −1 respectively and the DL was 0.046 μM in the linear range of 0.1–10.0 μM. The sensor is simple, inexpensive and uses blood serum. Abstract :