A Rare Case of Famotidine-Induced Delirium in a Peritoneal Dialysis Patient. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Chan, Gary C.W.; Lee, K.M.; Kwan, Lorraine P.Y.; Mok, Maggie M.Y.; Ma, Maggie K.M.; Yap, Desmond Y.H.; Tang, Sydney C.W.
• Is Part Of: Peritoneal dialysis international. Volume 37:Issue 1(2017)
• Page Start: 118
• Page End: 120
• Publication Date: 2017-01
• Subjects: Delirium -- end-stage renal failure -- famotidine -- H2 receptor antagonists -- peritoneal dialysis; Peritoneal dialysis -- Periodicals; Continuous ambulatory peritoneal dialysis -- Periodicals; 617.461059
• DOI: 10.3747/pdi.2016.00145
• Languages: English
• ISSNs: 0896-8608

Abstract

H2 receptor antagonists are commonly employed to manage gastro-esophageal reflux and peptic ulcer diseases with a very low incidence of side effects. Herein, we report an extremely rare incidence of famotidine-induced acute confusion in a patient with end-stage renal failure. We also discuss the pharmacokinetic properties of famotidine and its interplay with compromised renal function to result in neuropsychiatric manifestations, highlighting the importance of dosage adjustment in individuals with renal insufficiency.