RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers. Issue 6 (21st April 2020)
- Record Type:
- Journal Article
- Title:
- RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers. Issue 6 (21st April 2020)
- Main Title:
- RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
- Authors:
- Biswas, Kajal
Sharan, Shyam K. - Abstract:
- Abstract : Adamson et al . report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair by homologous recombination and RAD52‐mediated single‐strand annealing may result in cell death and reduce breast cancer risk. Comment on: https://doi.org/10.1002/1878-0261.12665
- Is Part Of:
- Molecular oncology. Volume 14:Issue 6(2020)
- Journal:
- Molecular oncology
- Issue:
- Volume 14:Issue 6(2020)
- Issue Display:
- Volume 14, Issue 6 (2020)
- Year:
- 2020
- Volume:
- 14
- Issue:
- 6
- Issue Sort Value:
- 2020-0014-0006-0000
- Page Start:
- 1121
- Page End:
- 1123
- Publication Date:
- 2020-04-21
- Subjects:
- Cancer -- Molecular aspects -- Periodicals
616.994005 - Journal URLs:
- http://www.journals.elsevier.com/molecular-oncology/ ↗
http://febs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)1878-0261/issues/ ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1002/1878-0261.12679 ↗
- Languages:
- English
- ISSNs:
- 1574-7891
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5900.817993
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 13282.xml