Electrocardiographic features of the presence of occult myocardial disease in patients with VPD‐induced cardiomyopathy. Issue 3 (5th March 2020)

• Record Type: Journal Article
• Authors: Im, Sung Il; Gwag, Hye Bin; Park, Youngjun; Park, Seung‐Jung; Kim, June Soo; On, Young Keun; Park, Kyoung‐Min
• Is Part Of: Journal of arrhythmia. Volume 36:Issue 3(2020)
• Page Start: 485
• Page End: 492
• Publication Date: 2020-03-05
• Subjects: cardiomyopathy -- electrocardiogram -- ventricular premature depolarization; Arrhythmia -- Periodicals; Cardiac pacing -- Periodicals; Arrhythmias, Cardiac; Arrhythmia; Cardiac pacing; Periodicals; Electronic journals; Periodicals; 616.128
• DOI: 10.1002/joa3.12324
• Languages: English
• ISSNs: 1880-4276

Abstract

Abstract: Background: Frequent ventricular premature depolarizations (VPDs) can cause reversible cardiomyopathy (CMP). However, many patients maintain a normal left ventricular (LV) function with a high VPD burden. The electrocardiographic characteristics of VPD‐induced CMP have not been elucidated. Methods: One hundred and eighty (91 men, age; 51 ± 15 years) patients with frequent idiopathic VPDs (>10% VPDs/day or >10 000 VPDs/day) were studied. All patients underwent successful ablation and were then divided into two groups according to the echocardiographic findings before and after the ablation procedure. Results: Group A (n = 139) had a normal LV function with VPD frequencies, and Group B (n = 41) had reversible LV dysfunction after ablation. The VPD QRS duration (QRSd) was wider in patients with CMP (Group A vs Group B; 137.2 ± 12.0 milliseconds vs 159.7 ± 5.3 milliseconds, P < .001). VPDs with a terminal QRS delay marked by a notch followed by a discrete lower amplitude signal after the peak R wave in any precordial lead were identified. The incidence of terminal signals was higher in the CMP group (Group A vs Group B; 2.1% vs 53.6%, P < .001). Conclusions: The wider VPD QRSd and terminal QRS delay in patients with VPD‐induced CMP suggest subclinical cell‐to‐cell conduction abnormalities as a potential factor predisposing VPD‐induced CMP. Abstract : Figure 1 Eletrocardiographic parameters. A, CI and post‐VPD CI; B, QR and RS interval and amplitude; C, r/R transition interval; D, Initial and terminal Angle of VPD. Abbreviations: CI, coupling interval; SCL, sinus cycle length; VPD, ventricular premature depolarization