An Addition of Terminal Alkynes to Phthalazin‐2‐Ium Bromide Catalyzed by Copper. Issue 12 (17th April 2020)

• Record Type: Journal Article
• Authors: Chen, Qian; Luo, Mingjian; Guo, Fang; Liang, Kun; Zhou, Fanrui; Gao, Guolin
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 12(2020)
• Page Start: 2332
• Page End: 2336
• Publication Date: 2020-04-17
• Subjects: Addition -- Terminal Alkyne -- Phthalazin-2-ium Bromide -- Copper; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000053
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalyzed addition of alkynes to phthalazin‐2‐ium bromide has been developed under mild conditions, leading to the production of propargylamines analogues. The addition products of a broad scope of phthalazin‐2‐ium bromides bearing various N ‐benzyl or alkyl can be obtained in good to high yields. Moderate enantioselectivity was observed in preliminary screening studies of chiral organic ligand. Abstract :