Nuclear but not mitochondrial‐encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Issue 5 (25th October 2016)

• Record Type: Journal Article
• Authors: Mastroeni, Diego; Khdour, Omar M.; Delvaux, Elaine; Nolz, Jennifer; Olsen, Gary; Berchtold, Nicole; Cotman, Carl; Hecht, Sidney M.; Coleman, Paul D.
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 5(2017)
• Page Start: 510
• Page End: 519
• Publication Date: 2016-10-25
• Subjects: Aging -- Alzheimer's disease -- Mild cognitively impaired (MCI) -- Mitochondria -- Oxidative phosphorylation‐related genes expression -- Microarray -- Postmortem brains; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2016.09.003
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects. Methods: Hippocampal tissues from 44 non‐AD controls (NC), 10 amnestic MCI, and 18 AD cases were analyzed on Affymetrix Hg‐U133 plus 2.0 arrays. Results: The microarray data revealed significant down regulation in OXPHOS genes in AD, particularly those encoded in the nucleus. In contrast, there was up regulation of the same gene(s) in MCI subjects compared to AD and ND cases. No significant differences were observed in mtDNA genes identified in the array between AD, ND, and MCI subjects except one mt‐ND6 . Discussion: Our findings suggest that restoration of the expression of nuclear‐encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression.