Front Cover: Multitarget Compounds for Bipolar Disorder: From Rational Design to Preliminary Pharmacokinetic Evaluation (ChemMedChem 11/2020). (18th May 2020) - Di Martino, Rita Maria Concetta
Abstract : The Front Cover summarizes the idea of developing molecules potentially active in the treatment of bipolar disorder, a mental condition in which episodes of mania alternate with depression. Within the framework of polypharmacology, the authors have rationally developed compounds that concurrently modulate two targets implicated in bipolar disorder: the dopamine receptor D3 and glycogen synthase kinase 3β. More information can be found in the Communication by Federica Belluti, Andrea Cavalli et al.