Cutaneous crospovidone reaction secondary to subcutaneous injection of buprenorphine. (15th December 2019)

• Record Type: Journal Article
• Authors: Marka, Arthur; Hoyt, Brian S.; Dagrosa, Alicia T.; Barton, Dorothea T.; Kim, Andrew; Linos, Konstantinos; Yan, Shaofeng
• Is Part Of: Journal of cutaneous pathology. Volume 47:Number 5(2020)
• Page Start: 470
• Page End: 474
• Publication Date: 2019-12-15
• Subjects: Crospovidone -- drug abuse -- foreign body -- polyvinylpolypyrrolidone -- skin popping; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13624
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Crospovidone is an insoluble pharmaceutical disintegrant that has been implicated in a rare foreign body reaction in injection drug users, classically associated with pulmonary angiothrombosis. We recently reported the first known cases of cutaneous crospovidone deposition. We herein report two additional cases with unique clinicopathologic manifestations, both in the setting of suspected injection drug abuse. Additionally, we provide a comprehensive overview of the distinct histomorphology and reproducible histochemistry of crospovidone.