Fluorescence Self‐Reporting Precipitation Polymerization Based on Aggregation‐Induced Emission for Constructing Optical Nanoagents. (9th January 2020)

• Record Type: Journal Article
• Authors: Wang, Guan; Zhou, Liangyu; Zhang, Pengfei; Zhao, Engui; Zhou, Lihua; Chen, Dong; Sun, Jiangman; Gu, Xinggui; Yang, Wantai; Tang, Ben Zhong
• Is Part Of: Angewandte Chemie. Volume 132:Number 25(2020)
• Page Start: 10208
• Page End: 10214
• Publication Date: 2020-01-09
• Subjects: Aggregationsinduzierte Emission -- Optische Nanoagenzien -- Photokontrollierbare Immuntherapie -- Fällungspolymerisation -- Fluoreszenz; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201913847
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Precipitation polymerization is becoming increasingly popular in energy, environment and biomedicine. However, its proficient utilization highly relies on the mechanistic understanding of polymerization process. Now, a fluorescence self‐reporting method based on aggregation‐induced emission (AIE) is used to shed light on the mechanism of precipitation polymerization. The nucleation and growth processes during the copolymerization of a vinyl‐modified AIEgen, styrene, and maleic anhydride can be sensitively monitored in real time. The phase‐separation and dynamic hardening processes can be clearly discerned by tracking fluorescence changes. Moreover, polymeric fluorescent particles (PFPs) with uniform and tunable sizes can be obtained in a self‐stabilized manner. These PFPs exhibit biolabeling and photosensitizing abilities and are used as superior optical nanoagents for photo‐controllable immunotherapy, indicative of their great potential in biomedical applications. Abstract : Eine Fluoreszenzmethode, die auf aggregationsinduzierter Emission basiert, wurde entwickelt, um den Mechanismus der Fällungspolymerisation zu erforschen. Morphologie und Mikroveränderungen der Umgebung werden in den Nukleations‐ und Wachstumsprozessen erkannt. Polymere fluoreszierende Partikel mit einheitlicher und steuerbarer Größe sind so konzipiert, dass sie als optische Nanoagenzien für die photokontrollierbare Immuntherapie dienen können.