A point‐based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease. Issue 6 (3rd February 2014)

• Record Type: Journal Article
• Authors: Barnes, Deborah E.; Cenzer, Irena S.; Yaffe, Kristine; Ritchie, Christine S.; Lee, Sei J.
• Is Part Of: Alzheimer's & dementia. Volume 10:Issue 6(2014)
• Page Start: 646
• Page End: 655
• Publication Date: 2014-02-03
• Subjects: Alzheimer's disease -- Mild cognitive impairment -- Prognostic modeling -- Risk factors -- Aged -- Human -- Magnetic resonance imaging -- Neuropsychological tests -- Disease progression; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2013.12.014
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: Our objective in this study was to develop a point‐based tool to predict conversion from amnestic mild cognitive impairment (MCI) to probable Alzheimer's disease (AD). Methods: Subjects were participants in the first part of the Alzheimer's Disease Neuroimaging Initiative. Cox proportional hazards models were used to identify factors associated with development of AD, and a point score was created from predictors in the final model. Results: The final point score could range from 0 to 9 (mean 4.8) and included: the Functional Assessment Questionnaire (2‒3 points); magnetic resonance imaging (MRI) middle temporal cortical thinning (1 point); MRI hippocampal subcortical volume (1 point); Alzheimer's Disease Cognitive Scale—cognitive subscale (2‒3 points); and the Clock Test (1 point). Prognostic accuracy was good (Harrell's c = 0.78; 95% CI 0.75, 0.81); 3‐year conversion rates were 6% (0‒3 points), 53% (4‒6 points), and 91% (7‒9 points). Conclusions: A point‐based risk score combining functional dependence, cerebral MRI measures, and neuropsychological test scores provided good accuracy for prediction of conversion from amnestic MCI to AD.