Cooperative Application of Conventional and Microwave Heating. Issue 6 (18th May 2020)

• Record Type: Journal Article
• Authors: Fulo, Harvey F.; Vincent, Morgan A.; Stiegman, Albert E.; Dudley, Gregory B.
• Is Part Of: Asian journal of organic chemistry. Volume 9:Issue 6(2020)
• Page Start: 961
• Page End: 966
• Publication Date: 2020-05-18
• Subjects: microwave chemistry -- selective heating -- Friedel-Crafts -- reaction kinetics -- reaction engineering; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202000157
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: The coordinated, cooperative use of microwave heating with conventional heating can provide advantages in chemical synthesis. Here, heterogeneous mixtures comprising ionic, highly microwave‐absorbing organic reagents and nearly microwave‐transparent arene solvents are heated conventionally and/or with microwaves, resulting in faster and, in some cases, higher yielding reactions when the two heating methods are applied cooperatively as compared to either method independently. Control experiments in more polar arene solvents show no advantage of cooperative heating, consistent with selective microwave heating phenomena. The experiments are facilitated by reactor technology that regulates internal reaction temperature and coordinates the application of conventional and microwave heating. The positive outcomes in this initial exploratory system suggest that cooperative heating can offer benefits in other systems designed for selective microwave heating. Abstract : Complementary heating modes working together can improve chemical reaction outcomes. Using innovative reactor technology and a strongly microwave‐absorbing reagent, thermal Friedel‐Crafts benzylation reactions of nonpolar aromatic rings are faster and/or more efficient using cooperative heating than with either conventional or microwave heating alone.