Self‐Assembled Peptide‐Based Nanoprobes for Disease Theranostics and Disease‐Related Molecular Imaging. Issue 4 (22nd August 2019)

• Record Type: Journal Article
• Authors: Ren, Chunhua; Wang, Zhongyan; Wang, Qian; Yang, Cuihong; Liu, Jianfeng
• Is Part Of: Small methods. Volume 4:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-22
• Subjects: bacterial infection diagnosis -- cancer theranostics -- cell imaging -- molecular imaging -- self‐assembled peptides; Nanotechnology -- Methodology -- Periodicals; Nanotechnology -- Periodicals; Periodicals; 620.5028
• DOI: 10.1002/smtd.201900403
• Languages: English
• ISSNs: 2366-9608

Abstract

Abstract: Self‐assembling peptide‐based nanoprobes have attracted increasing research interest in recent years because of their inherent advantages, such as good biosafety, flexible designability, ease of synthesis, and degradability. Being precisely regulated by a delicate molecular design, the self‐assembly/disassembly behavior of the peptide‐based nanoprobes to external stimuli results in signal turn‐on/off properties, which can therefore be applied for disease theranostics and disease‐related molecular detection, including cancer, bacterial infection, cell imaging, and enzymes. This review summarizes the recent advancements of self‐assembled peptide‐based nanoprobes for disease diagnosis and molecular imaging. Moreover, the challenges and strategies of self‐assembled peptide‐based nanoprobes for clinic transformation and practical applications are briefly discussed. Abstract : Recent advances in disease diagnosis and molecular imaging using self‐assembled peptide‐based nanoprobes are highlighted in this review, including cancer theranostics, infection diagnosis, disease‐related molecular detection, and cell imaging. Through delicate molecular design, diverse imaging modalities can be introduced into self‐assembled peptide‐based nanoprobes, which possess great potential for clinical translation in the future.