Quantification of regional myocardial mean intracellular water lifetime: A nonhuman primate study in myocardial stress. (24th January 2020)

• Record Type: Journal Article
• Authors: Sampath, Smita; Parimal, Annamalai Sarayu; Huang, Wei; Manigbas, Elaine; Gsell, Willy; Chang, Miko May Lee; Qiu, Anqi; Jacobsen, Kirsten; Evelhoch, Jeffrey L.; Chin, Chih‐Liang
• Is Part Of: NMR in biomedicine. Volume 33:Number 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-24
• Subjects: cardiac magnetic resonance imaging -- cardiac stress -- dynamic contrast‐enhanced magnetic resonance imaging -- mean intracellular water lifetime -- myocardial strain; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4248
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : Heart failure with preserved ejection fraction (HFpEF) is typically associated with early metabolic remodeling. Noninvasive imaging biomarkers that reflect these changes will be crucial in determining responses to early drug interventions in these patients. Mean intracellular water lifetime (τi ) has been shown to be partially inversely related to Na, K‐ATPase transporter activity and may thus provide insight into the metabolic status in HFpEF patients. Here, we aim to perform regional quantification of τi using dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in the nonhuman primate (NHP) heart and evaluate its region‐specific variations under conditions of myocardial stress in the context of perturbed myocardial function. Cardiac stress was induced in seven naïve cynomolgus macaques using a dobutamine stepwise infusion protocol. All animals underwent 3 T cardiac dual‐bolus DCE and tagging MRI experiments. The shutter‐speed model was employed to quantify regional τi from the DCE‐MR images. Additionally, τi values were correlated with myocardial strains. During cardiac stress, there was a significant decrease in global τi (192.9 ± 76.3 ms vs 321.6 ± 70 ms at rest, P < 0.05) in the left ventricle, together with an increase in global peak circumferential strain (−15.4% ± 2.7% vs −10.1% ± 2.9% at rest, P < 0.05). Specifically, slice‐level analysis further revealed that a greater significant decrease in mean τi was observed in the apical region (ΔτI = 182.4 ms) compared with the basal (Δτi = 113.2 ms) and midventricular regions (Δτi = 108.4 ms). Regional analysis revealed that there was a greater significant decrease in mean τi in the anterior (Δτi = 243.9 ms) and antero‐lateral (Δτi = 177.2 ms) regions. In the inferior and infero‐septal regions, although a decrease in τi was observed, it was not significant. Whole heart regional quantification of τi is feasible using DCE‐MRI. τi is sensitive to regional changes in metabolic state during cardiac stress, and its value correlates with strain. Abstract : Heart Failure with preserved ejection fraction (HFpEF) is typically associated with early metabolic remodelling that contributes to abnormal cellular water transport. Mean intracellular water lifetime (τi ) may provide insight into early remodelling in HFpEF patients. Herein, τi appears to be sensitive to regional changes in water transport activity during cardiac stress, and its value correlates with circumferential strain (CS). Overall, there is a decrease in τi during stress as compared to resting conditions, partially reflecting increased metabolic activity during stress.