Miro: A molecular switch at the center of mitochondrial regulation. (24th February 2020)

• Record Type: Journal Article
• Authors: Eberhardt, Emily L.; Ludlam, Anthony V.; Tan, Zhenyu; Cianfrocco, Michael A.
• Is Part Of: Protein science. Volume 29:Number 6(2020)
• Page Start: 1269
• Page End: 1284
• Publication Date: 2020-02-24
• Subjects: GTPase -- microtubule transport -- Miro -- mitochondria -- neurodegeneration -- organelle contact sites; Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.3839
• Languages: English
• ISSNs: 0961-8368

Abstract

Abstract: The orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections between organelles and the cytoskeleton that range from mediating contacts between the endoplasmic reticulum and mitochondria to the regulation of both actin and microtubule motor proteins. Recently, a number of cell biological, biochemical, and protein structure studies have helped to characterize the myriad roles played by Miro. In addition to answering questions regarding Miro's function, these studies have opened the door to new avenues in the study of Miro in the cell. This review will focus on summarizing recent findings for Miro's structure, function, and activity while highlighting key questions that remain unanswered.