Microwave assisted synthesis, docking and antimalarial evaluation of hybrid PABA‐substituted 1, 3, 5‐triazine derivatives. (15th March 2020)

• Record Type: Journal Article
• Authors: Adhikari, Nayana; Kashyap, Ankita; Shakya, Anshul; Ghosh, Surajit Kumar; Bhattacharyya, Dibya Ranjan; Bhat, Hans Raj; Singh, Udaya Pratap
• Is Part Of: Journal of heterocyclic chemistry. Volume 57:Number 6(2020)
• Page Start: 2389
• Page End: 2399
• Publication Date: 2020-03-15
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3955
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: A series of novel PABA‐substituted 1, 3, 5‐triazine derivatives were developed via microwave assisted synthesis and subsequently tested for antimalarial activity against chloroquine sensitive 3D7 strain of Plasmodium falciparum using chloroquine as standard. Antimalarial screening result showed that synthesized compounds exhibited IC50 in the range of 4.46 to 79.72 μg mL −1 . Among the tested compounds, 4c and 4f showed significant antimalarial activity with low binding energies (BE) ‐172.32 and 160.41 kcal mol −1 via interacting with Arg122 through the involvement of COOH of the phenyl linked to 1, 3, 5‐triazine. In conclusion, these core scaffolds can be used for future antimalarial drug development. Abstract : SAR study of hybrid PABA substituted 1, 3, 5‐triazine derivatives.