Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment. Issue 3 (18th March 2020) - Jiang, Linye
Abstract: Photodynamic therapy (PDT), as an emerging clinical approach, has been exploited for the treatment of various diseases including cancer for several years. Excitation light and molecular oxygen are the key parameters that restrict the efficacy of PDT due to the restricted penetration depth of light and the hypoxic microenvironment of tumors, which will lead to ineffective therapeutic response. In recent years, a number of studies were focused on tackling these challenges and showed great potential in improving the efficacy of PDT to some degree. Herein, we summarize the advancements in newly developed PDT strategies based on diverse nanocomposites, especially in the aspects of the types of light source and the ways to supply oxygen. Finally, new challenges and possible opportunities for further research are also discussed. Abstract : Going deeper : This Minireview summarizes a variety of nanocomposite‐based approaches that overcome the existing limitations of photodynamic therapy, including NIR/X‐ray/self‐luminescence excited PDT and oxygen self‐supplying strategies through oxygen production or delivery. Examples include a system based on hemoglobin‐linked conjugated polymer nanoparticles that shows a great potential for deep tumor treatment.