Manual vs automated 68Ga‐radiolabelling—A comparison of optimized processes. (26th February 2020)

• Record Type: Journal Article
• Authors: Meisenheimer, Michael; Kürpig, Stefan; Essler, Markus; Eppard, Elisabeth
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 63:Number 4(2020)
• Page Start: 162
• Page End: 173
• Publication Date: 2020-02-26
• Subjects: automation -- cassette module -- clinical routine -- gallium‐68 -- DOTA‐TOC -- PSMA‐11; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3821
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract: A critical factor for clinical practice is the production of 68 Ga radiopharmaceuticals manufactured manually or through an automated procedure. 68 Ga radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The present work compares 68 Ga‐radiolabelling (PSMA‐11; DOTA‐TOC) utilizing a cassette module (GAIA; Elysia‐Raytest; Germany) with a manual setup for routine clinical production with regard to process reliability and reproducibility. Abstract : A critical factor for clinical practice is the production of 68 Ga‐radiopharmaceuticals manufactured manually or through an automated procedure. 68 Ga‐radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The automated process is superior to manual method in all categories and presents significant improvements of 68 Ga‐radiolabeling for routine clinical production in terms of reliability and reproducibility with the additional advantage of reduced operator's radiation exposure.