Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study. Issue 2 (16th January 2017)

• Record Type: Journal Article
• Authors: Corrada, María M.; Hayden, Kathleen M.; Paganini-Hill, Annlia; Bullain, Szofia S.; DeMoss, Jaime; Aguirre, Colette; Brookmeyer, Ron; Kawas, Claudia H.
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 2(2017)
• Page Start: 103
• Page End: 110
• Publication Date: 2017-01-16
• Subjects: Hypertension -- Blood pressure -- Dementia -- Oldest-old -- Epidemiology -- Risk factors; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2016.09.007
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: We investigated the association between age of onset of hypertension and dementia risk in an oldest‐old cohort. Methods: Participants are from The 90+ Study, a population‐based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self‐reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years. Results: A total of 224 participants developed dementia during follow‐up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004). Discussion: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.